Levels of Prostaglandin E Metabolite and Leukotriene E(4) Are Increased in the Urine of Smokers. Evidence that Celecoxib Shunts Arachidonic Acid into the 5-Lipoxygenase Pathway

Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) play a role in inflammation and carcinogenesis. Biomarkers that reflect tobacco smoke-induced tissue injury are needed. In this study, levels of urinary prostaglandin E metabolite (PGE-M) and leukotriene E(4) (LTE(4)), biomarkers of the COX and 5-LO...

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Main Authors: Duffield-Lillico, Anna J., Boyle, Jay O., Zhou, Xi Kathy, Ghosh, Aradhana, Butala, Geera S., Subbaramaiah, Kotha, Newman, Robert A., Morrow, Jason D., Milne, Ginger L., Dannenberg, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745265/
https://ncbi.nlm.nih.gov/pubmed/19336727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0005
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