Interference with RUNX1/ETO Leukemogenic Function by Cell-Penetrating Peptides Targeting the NHR2 Oligomerization Domain

The leukemia-associated fusion protein RUNX1/ETO is generated by the chromosomal translocation t(8;21) which appears in about 12% of all de novo acute myeloid leukemias (AMLs). Essential for the oncogenic potential of RUNX1/ETO is the oligomerization of the chimeric fusion protein through the nervy...

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Hlavní autoři: Bartel, Yvonne, Grez, Manuel, Wichmann, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707205/
https://ncbi.nlm.nih.gov/pubmed/23865046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/297692
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