Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer’s disease

Inflammation has been associated with the two classic lesions in the Alzheimer’s (AD) brain, amyloid deposits and neurofibrillary tangles. Recent data suggest that Triflusal, a compound with potent anti-inflammatory effects in the central nervous system in vivo, might delay the conversion from amnes...

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Main Authors: Coma, M., Serenó, L., Rocha-Souto, B. Da, Scotton, T.C., España, J., Sánchez, M.B., Rodríguez, M., Agulló, J., Guardia-Laguarta, C., Garcia-Alloza, M., Borrelli, L.A., Clarimón, J., Lleó, A., Bacskai, B.J., Saura, C.A., Hyman, B.T., Gómez-Isla, T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707138/
https://ncbi.nlm.nih.gov/pubmed/20149872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.01.019
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