Indoxyl Sulfate Down-Regulates SLCO4C1 Transporter through Up-Regulation of GATA3

The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins. However, the precise mechanism of the nephrotoxicity of uremic toxins on renal transport has been poorly...

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Main Authors: Akiyama, Yasutoshi, Kikuchi, Koichi, Saigusa, Daisuke, Suzuki, Takehiro, Takeuchi, Yoichi, Mishima, Eikan, Yamamoto, Yasuaki, Ishida, Ayako, Sugawara, Daiki, Jinno, Daisuke, Shima, Hisato, Toyohara, Takafumi, Suzuki, Chitose, Souma, Tomokazu, Moriguchi, Takashi, Tomioka, Yoshihisa, Ito, Sadayoshi, Abe, Takaaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706553/
https://ncbi.nlm.nih.gov/pubmed/23874392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066518
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