ErbB2 requires integrin α5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

ErbB2, a receptor tyrosine kinase highly expressed in many tumors, is known to inhibit apoptotic signals. Overexpression of ErbB2 causes anoikis resistance that contributes to luminal filling in three-dimensional mammary epithelial acinar structures in vitro. Given that integrins and growth factor r...

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Autors principals: Haenssen, Keneshia K., Caldwell, Sarah A., Shahriari, Kristina S., Jackson, S. RaElle, Whelan, Kelly A., Klein-Szanto, Andres J., Reginato, Mauricio J.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705932/
https://ncbi.nlm.nih.gov/pubmed/20332114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.050906
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