OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity are u...

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Bibliografiska uppgifter
Huvudupphovsmän: Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705208/
https://ncbi.nlm.nih.gov/pubmed/23827681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.046
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