P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. Also PRODH2, which degrades 4-hydroxy-L-proline, a product of protein (e.g. collagen) cata...

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Bibliographische Detailangaben
Hauptverfasser: Raimondi, Ivan, Ciribilli, Yari, Monti, Paola, Bisio, Alessandra, Pollegioni, Loredano, Fronza, Gilberto, Inga, Alberto, Campomenosi, Paola
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704516/
https://ncbi.nlm.nih.gov/pubmed/23861960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069152
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