Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.

Dichloroacetate (DCA) markedly reduces circulating cholesterol levels in animals and in patients with combined hyperlipoproteinemia or homozygous familial hypercholesterolemia (FH). To investigate the mechanism of its cholesterol-lowering action, we studied the effects of DCA and its hepatic metabol...

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Bibliografski detalji

Izdano u:	J Clin Invest
Glavni autori:	Stacpoole, P W, Harwood, H J, Varnado, C E
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 1983
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6630519/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111116
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