Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.

Dichloroacetate (DCA) markedly reduces circulating cholesterol levels in animals and in patients with combined hyperlipoproteinemia or homozygous familial hypercholesterolemia (FH). To investigate the mechanism of its cholesterol-lowering action, we studied the effects of DCA and its hepatic metabol...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Stacpoole, P W, Harwood, H J, Varnado, C E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6630519/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111116
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