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Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy

Abnormal assemblies formed by misfolded superoxide dismutase-1 (SOD1) proteins are the likely cause of SOD1-linked familial amyotrophic lateral sclerosis (fALS) and may be involved in some cases of sporadic ALS. To analyze the structure of the insoluble SOD1 amyloid fibrils, we first used limited pr...

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Bibliografiske detaljer
Main Authors: Chan, Pik K., Chattopadhyay, Madhuri, Sharma, Shivani, Souda, Puneet, Gralla, Edith Butler, Borchelt, David R., Whitelegge, Julian P., Valentine, Joan Selverstone
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704032/
https://ncbi.nlm.nih.gov/pubmed/23781106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309613110
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