Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer’s disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that amyloid-β peptide (Aβ) engages α7 nicotinic acetylch...

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Main Authors: Talantova, Maria, Sanz-Blasco, Sara, Zhang, Xiaofei, Xia, Peng, Akhtar, Mohd Waseem, Okamoto, Shu-ichi, Dziewczapolski, Gustavo, Nakamura, Tomohiro, Cao, Gang, Pratt, Alexander E., Kang, Yeon-Joo, Tu, Shichun, Molokanova, Elena, McKercher, Scott R., Hires, Samuel Andrew, Sason, Hagit, Stouffer, David G., Buczynski, Matthew W., Solomon, James P., Michael, Sarah, Powers, Evan T., Kelly, Jeffery W., Roberts, Amanda, Tong, Gary, Fang-Newmeyer, Traci, Parker, James, Holland, Emily A., Zhang, Dongxian, Nakanishi, Nobuki, Chen, H.-S. Vincent, Wolosker, Herman, Wang, Yuqiang, Parsons, Loren H., Ambasudhan, Rajesh, Masliah, Eliezer, Heinemann, Stephen F., Piña-Crespo, Juan C., Lipton, Stuart A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
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PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704025/
https://ncbi.nlm.nih.gov/pubmed/23776240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306832110
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