MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. In addition to its known receptor-mediated biological activities, MIF possesses a catalytic site of unknown function between subunits of a homotrimer. Each subunit contributes three β-strands to adjacent subunits to form a c...

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Bibliografiske detaljer
Main Authors: Fan, Chengpeng, Rajasekaran, Deepa, Syed, Mansoor Ali, Leng, Lin, Loria, J. Patrick, Bhandari, Vineet, Bucala, Richard, Lolis, Elias J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703972/
https://ncbi.nlm.nih.gov/pubmed/23776208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221817110
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