Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G(1) arrest through APC/C(Cdh1) regulation

DNA damage triggers cell cycle arrest to provide a time window for DNA repair. Failure of arrest could lead to genomic instability and tumorigenesis. DNA damage-induced G(1) arrest is generally achieved by the accumulation of Cyclin-dependent kinase inhibitor 1 (p21). However, p21 is degraded and do...

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Główni autorzy: Zhang, Wei-Na, Zhou, Jie, Zhou, Tao, Li, Ai-Ling, Wang, Na, Xu, Jin-Jing, Chang, Yan, Man, Jiang-Hong, Pan, Xin, Li, Tao, Li, Wei-Hua, Mu, Rui, Liang, Bing, Chen, Liang, Jin, Bao-Feng, Xia, Qing, Gong, Wei-Li, Zhang, Xue-Min, Wang, Li, Li, Hui-Yan
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2013
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703968/
https://ncbi.nlm.nih.gov/pubmed/23776205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221009110
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