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Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation

The Signal Transducer and Activator of Transcription factor STAT4 is a critical regulator of Th1 differentiation and inflammatory disease. Yet, how STAT4 regulates gene expression is still unclear. In this report, we define a STAT4-dependent sequence of events including H3K4 methylation, Jmjd3 assoc...

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Bibliografiske detaljer
Main Authors: Pham, Duy, Yu, Qing, Walline, Crystal C., Muthukrishnan, Rajarajeswari, Blum, Janice S., Kaplan, Mark H.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703830/
https://ncbi.nlm.nih.gov/pubmed/23772023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203229
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