Angiotensin II Contributes to Diabetic Renal Dysfunction in Rodents and Humans via Notch1/Snail Pathway

In nondiabetic rat models of renal disease, angiotensin II (Ang II) perpetuates podocyte injury and promotes progression to end-stage kidney disease. Herein, we wanted to explore the role of Ang II in diabetic nephropathy by a translational approach spanning from in vitro to in vivo rat and human st...

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Bibliographische Detailangaben
Hauptverfasser: Gagliardini, Elena, Perico, Norberto, Rizzo, Paola, Buelli, Simona, Longaretti, Lorena, Perico, Luca, Tomasoni, Susanna, Zoja, Carla, Macconi, Daniela, Morigi, Marina, Remuzzi, Giuseppe, Benigni, Ariela
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703549/
https://ncbi.nlm.nih.gov/pubmed/23707238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.03.025
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