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Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

AIMS/HYPOTHESIS: The NAD(+)-dependent protein deacetylase sirtuin (SIRT)1 is thought to be a key regulator of skeletal muscle metabolism. However, its precise role in the regulation of insulin sensitivity is unclear. Accordingly, we sought to determine the effect of skeletal muscle-specific overexpr...

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Détails bibliographiques
Auteurs principaux: White, A. T., McCurdy, C. E., Philp, A., Hamilton, D. L., Johnson, C. D., Schenk, S.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703320/
https://ncbi.nlm.nih.gov/pubmed/23604553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2912-2
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