Identifying and Targeting ROS1 Gene Fusions in Non-Small Cell Lung Cancer

PURPOSE: Oncogenic gene fusions involving the 3’ region of ROS1 kinase have been identified in various human cancers. In this study, we sought to characterize ROS1 fusion genes in non-small cell lung cancer (NSCLC) and establish the fusion proteins as drug targets. EXPERIMENTAL DESIGN: A NSCLC tissu...

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Huvudupphovsmän: Davies, Kurtis D., Le, Anh T., Theodoro, Mariana F., Skokan, Margaret C., Aisner, Dara L., Berge, Eamon M., Terracciano, Luigi M., Incarbone, Matteo, Roncalli, Massimo, Cappuzzo, Federico, Camidge, D. Ross, Varella-Garcia, Marileila, Doebele, Robert C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703205/
https://ncbi.nlm.nih.gov/pubmed/22919003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0550
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