Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment

Reversing tumor-associated immunosuppression appears necessary to stimulate effective therapeutic immunity against lethal epithelial tumors. Here, we show this goal can be addressed using cps, an avirulent, nonreplicating uracil auxotroph strain of the parasite Toxoplasma gondii, which preferentiall...

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Autores principales: Baird, Jason R., Fox, Barbara A., Sanders, Kiah L., Lizotte, Patrick H., Cubillos-Ruiz, Juan R., Scarlett, Uciane K., Rutkowski, Melanie R., Conejo-Garcia, Jose R., Fiering, Steven, Bzik, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702636/
https://ncbi.nlm.nih.gov/pubmed/23704211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1974
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