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Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted deletions of parasite secreted effector proteins usin...

詳細記述

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書誌詳細
出版年:PLoS Genet
主要な著者: Fox, Barbara A., Sanders, Kiah L., Rommereim, Leah M., Guevara, Rebekah B., Bzik, David J.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957766/
https://ncbi.nlm.nih.gov/pubmed/27447180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006189
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