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Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells

The advances in the treatment of chronic myeloid leukemia (CML) during the last years were also accompanied by the development of evading strategies by tumor cells, resulting in chemotherapy resistance in some patients. Patented organopalladium compounds derived from the reaction of N,N-dimethyl-1-p...

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Detalhes bibliográficos
Main Authors: Moraes, V W R, Caires, A C F, Paredes-Gamero, E J, Rodrigues, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702286/
https://ncbi.nlm.nih.gov/pubmed/23744358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.190
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