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Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

The current model of apoptosis holds that upstream signals lead to activation of downstream effector caspases. We generated mice deficient in the two effectors, caspase 3 and caspase 7, which died immediately after birth with defects in cardiac development. Fibroblasts lacking both enzymes were high...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Lakhani, Saquib A., Masud, Ali, Kuida, Keisuke, Porter, George A., Booth, Carmen J., Mehal, Wajahat Z., Inayat, Irteza, Flavell, Richard A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738210/
https://ncbi.nlm.nih.gov/pubmed/16469926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1115035
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