Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition

Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target in cancer and...

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Main Authors: Mohan, Pooja, Castellsague, Joan, Jiang, Jihong, Allen, Kristi, Chen, Helen, Nemirovsky, Oksana, Spyra, Melanie, Hu, Kaiji, Kluwe, Lan, Pujana, Miguel Angel, Villanueva, Alberto, Mautner, Victor F., Keats, Jonathan J., Dunn, Sandra E., Lazaro, Conxi, Maxwell, Christopher A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2013
נושאים:
Research Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702209/
https://ncbi.nlm.nih.gov/pubmed/23328114
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