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Chlorizidine, A Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp

[Image: see text] Cultivation of an obligate marine Streptomyces strain has provided the cytotoxic natural product chlorizidine. X-Ray crystallographic analysis revealed that the metabolite is composed of a chlorinated 2,3-dihydropyrrolizine ring attached to a chlorinated 5H-pyrrolo[2,1-a]isoindol-5...

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Main Authors: Alvarez-Mico, Xavier, Jensen, Paul R., Fenical, William, Hughes, Chambers C.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702164/
https://ncbi.nlm.nih.gov/pubmed/23405849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol303374e
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