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Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors

Compounds 1–4 were synthesized and investigated for selectivity and potency for the oxytocin receptor (OTR) to determine their viability as radioactive ligands. Binding assays determined 1–4 to have high binding affinity for both the human and rodent OTR and also have high selectivity for the human...

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Autori principali: Smith, Aaron L., Freeman, Sara M., Stehouwer, Jeffery S., Inoue, Kiyoshi, Voll, Ronald J., Young, Larry J., Goodman, Mark M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701955/
https://ncbi.nlm.nih.gov/pubmed/22425346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.019
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