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ABCA1 mediates unfolding of apoAI N-terminus on the cell surface prior to lipidation and release of nascent HDL
OBJECTIVE: To gain insight into the mechanism by which ABCA1 generates nascent HDL. APPROACH AND RESULTS: HEK293 cells were stably transfected with ABCA1 vectors encoding wild type (WT) and the W590S and C1477R Tangier disease mutation isoforms, along with the K939M ATP binding domain mutant. ApoAI...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701943/ https://ncbi.nlm.nih.gov/pubmed/23559627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.301195 |
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