ABCA1 mediates unfolding of apoAI N-terminus on the cell surface prior to lipidation and release of nascent HDL

OBJECTIVE: To gain insight into the mechanism by which ABCA1 generates nascent HDL. APPROACH AND RESULTS: HEK293 cells were stably transfected with ABCA1 vectors encoding wild type (WT) and the W590S and C1477R Tangier disease mutation isoforms, along with the K939M ATP binding domain mutant. ApoAI...

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Hlavní autoři: Wang, Shuhui, Gulshan, Kailash, Brubaker, Gregory, Hazen, Stanly L., Smith, Jonathan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701943/
https://ncbi.nlm.nih.gov/pubmed/23559627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.301195
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