DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations

Segmental progeroid syndromes are groups of disorders with multiple features suggestive of accelerated aging. One subset of adult-onset progeroid syndromes, referred to as atypical Werner syndrome, is caused by mutations in the LMNA gene, which encodes a class of nuclear intermediate filaments, lami...

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Detalhes bibliográficos
Main Authors: Saha, Bidisha, Zitnik, Galynn, Johnson, Simon, Nguyen, Quyen, Risques, Rosa A., Martin, George M., Oshima, Junko
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701863/
https://ncbi.nlm.nih.gov/pubmed/23847654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00129
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