Identification of Caveolin-1 as a Potential Causative Factor in the Generation of Trastuzumab Resistance in Breast Cancer Cells

The oncogenic tyrosine kinase receptor ErbB2 is a prognostic factor and target for breast cancer therapeutics. In contrast with the other ErbB receptors, ErbB2 is hardly internalized by ligand induced mechanisms, indicating a prevalent surface expression. Elevated levels of ErbB2 in tumor cells are...

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Autori principali: Sekhar, Sreeja C, Kasai, Tomonari, Satoh, Ayano, Shigehiro, Tsukasa, Mizutani, Akifumi, Murakami, Hiroshi, El-Aarag, Bishoy YA, Salomon, David S., Massaguer, Anna, de Llorens, Rafael, Seno, Masaharu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701809/
https://ncbi.nlm.nih.gov/pubmed/23833684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.6470
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