Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression

Invasion of fibroblast-like synoviocytes (FLSs) is critical in the pathogenesis of rheumatoid arthritis (RA). The metalloproteinases (MMPs) and activator of Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway play a critical role in RA-FLS invasion induced by lipopolysaccharide (LPS). The...

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Main Authors: Li, Guoqing, Liu, Dan, Zhang, Yu, Qian, Yayun, Zhang, Hua, Guo, Shiyu, Sunagawa, Masataka, Hisamitsu, Tadashi, Liu, Yanqing
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701694/
https://ncbi.nlm.nih.gov/pubmed/23861949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068905
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