Anti-invasive effects of Celastrus Orbiculatus extract on interleukin-1 beta and tumour necrosis factor-alpha combination-stimulated fibroblast-like synoviocytes

BACKGROUND: Invasion of fibroblast-like synoviocytes (FLSs) is critical in the pathogenesis of rheumatoid arthritis (RA). The metalloproteinases (MMPs) and activator of nuclear factor-kappa B (NF-κB) pathway play a critical role in RA-FLS invasion induced by interleukin-1 beta (IL-1β) and tumour nec...

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Main Authors: Li, Guoqing, Liu, Dan, Guo, Shiyu, Sunagawa, Masataka, Hisamitsu, Tadashi, Liu, Yanqing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938040/
https://ncbi.nlm.nih.gov/pubmed/24552146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-14-62
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