Preparation of 5′-O-(1-Thiotriphosphate)-Modified Oligonucleotides Using Polymerase-Endonuclease Amplification Reaction (PEAR)

Antisense oligonucleotides (ASODNs) have been widely used as an important tool for regulating gene expression, and developed into therapeutics. Natural ODNs are susceptible to nuclease degradation, nucleic acid analogues, however, have less side effects, stronger stability and more potent activities...

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Detalhes bibliográficos
Main Authors: Li, Biao, Dong, Shihua, Wu, Jiajun, Zhang, Jianye, Chen, Gang, Dong, Quanjiang, Zhu, Xinhong, Wang, Xiaolong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701678/
https://ncbi.nlm.nih.gov/pubmed/23861771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067558
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