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Polymerase-Endonuclease Amplification Reaction (PEAR) for Large-Scale Enzymatic Production of Antisense Oligonucleotides

Antisense oligonucleotides targeting microRNAs or their mRNA targets prove to be powerful tools for molecular biology research and may eventually emerge as new therapeutic agents. Synthetic oligonucleotides are often contaminated with highly homologous failure sequences. Synthesis of a certain oligo...

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Détails bibliographiques
Auteurs principaux: Wang, Xiaolong, Gou, Deming, Xu, Shuang-yong
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797076/
https://ncbi.nlm.nih.gov/pubmed/20062528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008430
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