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Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse
Nuclear factor κB (NF-κB) plays a pivotal role in sepsis. Activation of NF-κB is initiated by the signal-induced ubiquitylation and subsequent degradation of inhibitors of kappa B (IκBs) primarily via activation of the IκB kinase (IKK). This study was designed to investigate the effects of IKK inhib...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Company of Biologists Limited
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701222/ https://ncbi.nlm.nih.gov/pubmed/23649820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.012435 |
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