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LRRK2 GTPase Dysfunction in the Pathogenesis of Parkinson’s disease
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most frequent genetic cause of Parkinson’s disease (PD) and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTP...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701022/ https://ncbi.nlm.nih.gov/pubmed/22988868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20120093 |
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