Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA

Increased stabilization of mRNA coding for key cancer genes can contribute to invasiveness. This is achieved by down-regulation of exosome cofactors, which bind to 3'-UTR in cancer-related genes. Here, we identified amphiregulin, an EGFR ligand, as a target of WD repeat protein Monad, a compone...

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Autors principals: Saeki, Makio, Egusa, Hiroshi, Kamano, Yuya, Kakihara, Yoshito, Houry, Walid A., Yatani, Hirofumi, Noguchi, Shinzaburo, Kamisaki, Yoshinori
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701000/
https://ncbi.nlm.nih.gov/pubmed/23844004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067326
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