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RNA-dependent Protein Kinase PKR and the Z-DNA Binding Orthologue PKZ Differ in their Capacity to Mediate Initiation Factor eIF2α-dependent Inhibition of Protein Synthesis and Virus-induced Stress Granule Formation
Protein kinase R (PKR), a regulator of translation in mammalian cells, possesses two ds-RNA binding domains responsible for kinase activation. Protein kinase Z (PKZ), a PKR-like kinase present in fish, possesses two Z-DNA binding domains. A complementation strategy with cells stably deficient in PKR...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700635/ https://ncbi.nlm.nih.gov/pubmed/23706307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.04.020 |
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