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RNA-dependent Protein Kinase PKR and the Z-DNA Binding Orthologue PKZ Differ in their Capacity to Mediate Initiation Factor eIF2α-dependent Inhibition of Protein Synthesis and Virus-induced Stress Granule Formation

Protein kinase R (PKR), a regulator of translation in mammalian cells, possesses two ds-RNA binding domains responsible for kinase activation. Protein kinase Z (PKZ), a PKR-like kinase present in fish, possesses two Z-DNA binding domains. A complementation strategy with cells stably deficient in PKR...

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Bibliografiske detaljer
Main Authors: Taghavi, Nora, Samuel, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700635/
https://ncbi.nlm.nih.gov/pubmed/23706307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.04.020
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