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Protein Kinase PKR Amplification of Interferon β Induction Occurs through Initiation Factor eIF-2α-mediated Translational Control

The protein kinase PKR is activated by RNA with double-stranded (ds) structure and subsequently impairs translation through phosphorylation of protein synthesis initiation factor eIF-2α. PKR also mediates activation of signal transduction pathways leading to interferon beta (IFN-β) gene induction fo...

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Detalhes bibliográficos
Main Authors: McAllister, Christopher S., Taghavi, Nora, Samuel, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476304/
https://ncbi.nlm.nih.gov/pubmed/22948139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390039
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