Identification of a Small Molecule that induces ATG5-and-Cathepsin-L-Dependent Cell Death and modulates Polyglutamine Toxicity

Non-apoptotic cell death mechanisms are largely uncharacterized despite their importance in physiology and disease (P. Kreuzaler and C.J. Watson, Nature Reviews Cancer). Here we sought to systematically identify non-apoptotic cell death pathways in mammalian cells. We screened 69,612 compounds for t...

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Huvudupphovsmän: Varma, Hemant, Gangadhar, Nidhi M., Letso, Reka R., Wolpaw, Adam J., Sriramaratnam, Rohitha, Stockwell, Brent R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700633/
https://ncbi.nlm.nih.gov/pubmed/23588206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.03.019
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