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Identification of a Small Molecule that induces ATG5-and-Cathepsin-L-Dependent Cell Death and modulates Polyglutamine Toxicity

Non-apoptotic cell death mechanisms are largely uncharacterized despite their importance in physiology and disease (P. Kreuzaler and C.J. Watson, Nature Reviews Cancer). Here we sought to systematically identify non-apoptotic cell death pathways in mammalian cells. We screened 69,612 compounds for t...

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Bibliografiske detaljer
Main Authors: Varma, Hemant, Gangadhar, Nidhi M., Letso, Reka R., Wolpaw, Adam J., Sriramaratnam, Rohitha, Stockwell, Brent R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700633/
https://ncbi.nlm.nih.gov/pubmed/23588206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.03.019
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