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Identification of a Small Molecule that induces ATG5-and-Cathepsin-L-Dependent Cell Death and modulates Polyglutamine Toxicity
Non-apoptotic cell death mechanisms are largely uncharacterized despite their importance in physiology and disease (P. Kreuzaler and C.J. Watson, Nature Reviews Cancer). Here we sought to systematically identify non-apoptotic cell death pathways in mammalian cells. We screened 69,612 compounds for t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700633/ https://ncbi.nlm.nih.gov/pubmed/23588206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.03.019 |
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