COORDINATED ACTIVATION OF THE RAC-GAP β2-CHIMAERIN BY AN ATYPICAL PROLINE-RICH DOMAIN AND DIACYLGLYCEROL

Chimaerins, a family of GTPase activating proteins (GAPs) for the small G-protein Rac, have been implicated in development, neuritogenesis, and cancer. These Rac-GAPs are regulated by the lipid second messenger diacylglycerol (DAG) generated by tyrosine-kinases such as the epidermal growth factor re...

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Autori principali: Gutierrez-Uzquiza, Alvaro, Colon-Gonzalez, Francheska, Leonard, Thomas A., Canagarajah, Bertram J., Wang, HongBin, Mayer, Bruce J., Hurley, James H., Kazanietz, Marcelo G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700536/
https://ncbi.nlm.nih.gov/pubmed/23673634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2834
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