Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

Mutations in the lamin A/C gene (LMNA) encoding A-type lamins cause a diverse range of diseases collectively called laminopathies, the most common of which is dilated cardiomyopathy. Emerging evidence suggests that LMNA mutations cause disease by altering cell signaling pathways but the specific mec...

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Autores principales: Choi, Jason C., Muchir, Antoine, Wu, Wei, Iwata, Shinichi, Homma, Shunichi, Morrow, John P., Worman, Howard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700376/
https://ncbi.nlm.nih.gov/pubmed/22837537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003875
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