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Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation
Mutations in the lamin A/C gene (LMNA) encoding A-type lamins cause a diverse range of diseases collectively called laminopathies, the most common of which is dilated cardiomyopathy. Emerging evidence suggests that LMNA mutations cause disease by altering cell signaling pathways but the specific mec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700376/ https://ncbi.nlm.nih.gov/pubmed/22837537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003875 |
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