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Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway
Brca1 deficiency leads to the development of breast cancer. We previously found that Brca1 deficiency activates the Akt oncogenic pathway. Reduced expression of Brca1 was highly correlated with increased activated Akt in human breast cancer samples. Furthermore, activation of Akt1 was involved in Br...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700338/ https://ncbi.nlm.nih.gov/pubmed/22665067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.211 |
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