Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding

Human cytomegalovirus (HCMV) is a common agent of congenital infection and causes severe disease in immunocompromised patients. Current approved therapies focus on inhibiting viral DNA replication. The HCMV kinase pUL97 contributes to multiple stages of viral infection including DNA replication, con...

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Bibliografiske detaljer
Main Authors: Bigley, Tarin M., Reitsma, Justin M., Mirza, Shama P., Terhune, Scott S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700266/
https://ncbi.nlm.nih.gov/pubmed/23616659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02825-12
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