Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding

Human cytomegalovirus (HCMV) is a common agent of congenital infection and causes severe disease in immunocompromised patients. Current approved therapies focus on inhibiting viral DNA replication. The HCMV kinase pUL97 contributes to multiple stages of viral infection including DNA replication, con...

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Autores principales: Bigley, Tarin M., Reitsma, Justin M., Mirza, Shama P., Terhune, Scott S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700266/
https://ncbi.nlm.nih.gov/pubmed/23616659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02825-12
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