Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding

Human cytomegalovirus (HCMV) is a common agent of congenital infection and causes severe disease in immunocompromised patients. Current approved therapies focus on inhibiting viral DNA replication. The HCMV kinase pUL97 contributes to multiple stages of viral infection including DNA replication, con...

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Главные авторы: Bigley, Tarin M., Reitsma, Justin M., Mirza, Shama P., Terhune, Scott S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Genome Replication and Regulation of Viral Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700266/
https://ncbi.nlm.nih.gov/pubmed/23616659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02825-12
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