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Human Cytomegalovirus pUL29/28 and pUL38 Repression of p53-Regulated p21CIP1 and Caspase 1 Promoters during Infection

During infection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient viral gene expression, is stabilized. However, the expression of numerous p53-responsive cellular genes is not upregulated. The molecular mechanism used to manipulate the transcriptional acti...

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Detalhes bibliográficos
Main Authors: Savaryn, John P., Reitsma, Justin M., Bigley, Tarin M., Halligan, Brian D., Qian, Zhikang, Yu, Dong, Terhune, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571358/
https://ncbi.nlm.nih.gov/pubmed/23236067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01926-12
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