A Novel Bivalent Vaccine Based on a PB2-Knockout Influenza Virus Protects Mice from Pandemic H1N1 and Highly Pathogenic H5N1 Virus Challenges

Vaccination is an effective means to protect against influenza virus. Although inactivated and live-attenuated vaccines are currently available, each vaccine has disadvantages (e.g., immunogenicity and safety issues). To overcome these problems, we previously developed a replication-incompetent PB2-...

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Detalhes bibliográficos
Main Authors: Uraki, Ryuta, Kiso, Maki, Iwatsuki-Horimoto, Kiyoko, Fukuyama, Satoshi, Takashita, Emi, Ozawa, Makoto, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700221/
https://ncbi.nlm.nih.gov/pubmed/23658445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00076-13
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