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Enhanced growth of seed viruses for H5N1 influenza vaccines

Seed viruses used to produce inactivated H5N1 influenza vaccines are recombinant viruses with modified avirulent-type hemagglutinin (HA) and intact neuraminidase (NA) genes, both derived from an H5N1 isolate, and all remaining genes from the PR8 strain, which grows well in eggs. However, some reasso...

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Detalhes bibliográficos
Main Authors: Horimoto, Taisuke, Murakami, Shin, Muramoto, Yukiko, Yamada, Shinya, Fujii, Ken, Kiso, Maki, Iwatsuki-Horimoto, Kiyoko, Kino, Yoichiro, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827194/
https://ncbi.nlm.nih.gov/pubmed/17651774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.07.002
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