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Enhanced growth of seed viruses for H5N1 influenza vaccines

Seed viruses used to produce inactivated H5N1 influenza vaccines are recombinant viruses with modified avirulent-type hemagglutinin (HA) and intact neuraminidase (NA) genes, both derived from an H5N1 isolate, and all remaining genes from the PR8 strain, which grows well in eggs. However, some reasso...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Horimoto, Taisuke, Murakami, Shin, Muramoto, Yukiko, Yamada, Shinya, Fujii, Ken, Kiso, Maki, Iwatsuki-Horimoto, Kiyoko, Kino, Yoichiro, Kawaoka, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827194/
https://ncbi.nlm.nih.gov/pubmed/17651774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.07.002
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