A Bivalent Vaccine Based on a PB2-Knockout Influenza Virus Protects Mice From Secondary Pneumococcal Pneumonia

Background. Secondary bacterial infections after influenza can be a serious problem, especially in young children and the elderly, yet the efficacy of current vaccines is limited. Earlier work demonstrated that a replication-incompetent PB2-knockout (PB2-KO) influenza virus possessing a foreign gene...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Uraki, Ryuta, Piao, Zhenyu, Akeda, Yukihiro, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Ozawa, Makoto, Oishi, Kazunori, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655860/
https://ncbi.nlm.nih.gov/pubmed/26123562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv341
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