A Chemokine-Like Viral Protein Enhances Alpha Interferon Production by Plasmacytoid Dendritic Cells but Delays CD8(+) T Cell Activation and Impairs Viral Clearance

Murine cytomegalovirus encodes numerous proteins that act on a variety of pathways to modulate the innate and adaptive immune responses. Here, we demonstrate that a chemokine-like protein encoded by murine cytomegalovirus activates the early innate immune response and delays adaptive immunity, there...

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Main Authors: Wikstrom, Matthew E., Fleming, Peter, Comerford, Iain, McColl, Shaun R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700200/
https://ncbi.nlm.nih.gov/pubmed/23658453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00187-13
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